Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells

@article{Shoji2006MutualRB,
  title={Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells},
  author={Kazuo Shoji and Sofia Mariotto and Anna Rosa Ciampa and Hisanori Suzuki},
  journal={Neuroscience Letters},
  year={2006},
  volume={394},
  pages={163-167}
}
D-Serine indirectly caused dose- and time-dependent inhibition of neuronal nitric oxide synthase (nNOS) without affecting endothelial nitric oxide synthase (eNOS) in human glioblastoma cell line U87. Activity of D-amino acid oxidase (DAAO), catalyzing the oxidative deamination of d-amino acid, was enhanced by NO in a dose-dependent manner. Recently, we have reported that serine racemase (SR) is inhibited by NO and activated by D-serine through nitrosylation and denitrosylation, respectively [K… CONTINUE READING
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