• Chemistry, Medicine
  • Published in
    Organic & biomolecular…
  • DOI:10.1039/b415903a

Mutual induced fit in cyclodextrin-rocuronium complexes.

  title={Mutual induced fit in cyclodextrin-rocuronium complexes.},
  author={Alan Cooper and Margaret Nutley and Elizabeth J Maclean and Ken Cameron and Lee A. Fielding and Jordi Serra Mestres and Ronald Palin},
  journal={Organic & biomolecular chemistry},
  volume={3 10},
The binding of rocuronium bromide to 6-perdeoxy-6-per(4-carboxyphenyl)thio-gamma-cyclodextrin sodium salt, displays biphasic behaviour characteristic of the formation of a binary and 2 : 1 ternary guest-host complex in aqueous solution. Thermodynamic and structural data on this sequential complexation process can be rationalised within a single model involving switching of the conformational equilibria of both the rocuronium bromide and cyclodextrin molecules. Isothermal titration calorimetry… CONTINUE READING