Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains.

@article{Kim1999MutualAO,
  title={Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains.},
  author={William Y. Kim and Michael Sieweke and Eiko Ogawa and H J Wee and Ursula Englmeier and Thomas Graf and Yoshiaki Ito},
  journal={The EMBO journal},
  year={1999},
  volume={18 6},
  pages={1609-20}
}
The transcription factors Ets-1 and AML1 (the alphaBl subunit of PEBP2/CBF) play critical roles in hematopoiesis and leukemogenesis, and cooperate in the transactivation of the T cell receptor (TCR) beta chain enhancer. The DNA binding capacity of both factors is blocked intramolecularly but can be activated by the removal of negative regulatory domains. These include the exon VII domain for Ets-1 and the negative regulatory domain for DNA binding (NRDB) for alphaB1. Here we report that the… CONTINUE READING