Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species.

@article{Plaza2010MutremdamideAA,
  title={Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species.},
  author={Alberto Plaza and Giuseppe Bifulco and Milena Masullo and John R. Lloyd and Jessica L. Keffer and Patrick Lynn Colin and John N A Hooper and Lori J. Bell and Carole A. Bewley},
  journal={The Journal of organic chemistry},
  year={2010},
  volume={75 13},
  pages={
          4344-55
        }
}
A new sulfated cyclic depsipeptide, termed mutremdamide A, and six new highly N-methylated peptides, termed koshikamides C-H, were isolated from different deep-water specimens of Theonella swinhoei and Theonella cupola. Their structures were determined using extensive 2D NMR, ESI, or CDESI and QTOF-MS/MS experiments and absolute configurations established by quantum mechanical calculations, advanced Marfey's method, and chiral HPLC. Mutremdamide A displays a rare 2-amino-3-(2-hydroxyphenyl… Expand
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