Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools.

@article{Weinberg1981MutatorPI,
  title={Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools.},
  author={Geoffrey A. Weinberg and Buddy Ullman and Dwight W. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 4},
  pages={2447-51}
}
Recent studies of in vitro DNA synthesis have shown that fidelity of replication is influenced by the relative concentrations of deoxyribonucleoside triphosphates (dNTPs). Several investigators have used reconstituted prokaryotic replication systems to copy defined natural templates and have shown that specific incorporation errors can be induced by an appropriate bias of the precursor pools. The recent demonstration of mutator phenotypes among mutant Chinese hamster ovary cell lines with… CONTINUE READING

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