Mutator phenotypes due to DNA replication infidelity.

Abstract

This article considers the fidelity of DNA replication performed by eukaryotic DNA polymerases involved in replicating the nuclear genome. DNA replication fidelity can vary widely depending on the DNA polymerase, the composition of the error, the flanking sequence, the presence of DNA damage and the ability to correct errors. As a consequence, defects in… (More)
DOI: 10.1016/j.semcancer.2010.10.003

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Cite this paper

@article{Arana2010MutatorPD, title={Mutator phenotypes due to DNA replication infidelity.}, author={Mercedes E. Arana and Thomas A. Kunkel}, journal={Seminars in cancer biology}, year={2010}, volume={20 5}, pages={304-11} }