Mutations within the P2 Domain of Norovirus Capsid Affect Binding to Human Histo-Blood Group Antigens: Evidence for a Binding Pocket

@article{Tan2004MutationsWT,
  title={Mutations within the P2 Domain of Norovirus Capsid Affect Binding to Human Histo-Blood Group Antigens: Evidence for a Binding Pocket},
  author={Ming Tan and Pengwei Huang and Jarek Meller and Weiming Zhong and Tibor Farkas and Xi Jiang},
  journal={Journal of Virology},
  year={2004},
  volume={78},
  pages={3201 - 3201}
}
1 Citations

Mutations within the P2 Domain of Norovirus Capsid Affect Binding to Human Histo-Blood Group Antigens: Evidence for a Binding Pocket

Using multiple sequence alignments, homology modeling, and structural analysis of NOR capsids, a plausible “pocket” in the P2 domain that may be responsible for binding to HBGA receptors is identified and direct evidence of this hypothesis requires crystallography studies.