Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.

@article{Mungre1994MutationsWA,
  title={Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.},
  author={S. M. Mungre and K Enderle and Brian S. Turk and Anal{\'i}a I. Porr{\'a}s and Yong Qin Wu and Marc C. Mumby and Kathleen Rundell},
  journal={Journal of virology},
  year={1994},
  volume={68 3},
  pages={1675-81}
}
Three independent point mutations within residues 97 to 103 of the simian virus 40-small-t antigen (small-t) greatly reduced the ability of purified small-t to inhibit protein phosphatase 2A in vitro. These mutations affected the interaction of small-t antigen with the protein phosphatase 2A A subunit translated in vitro, and a peptide from the region identified by these mutations released the A subunit from immune complexes. When introduced into virus, the mutations eliminated the ability of… CONTINUE READING