Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP.

@article{Abdulkarim1994MutationsTK,
  title={Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP.},
  author={Farhad Abdulkarim and Lars Liljas and Diarmaid Hughes},
  journal={FEBS letters},
  year={1994},
  volume={352 2},
  pages={118-22}
}
The antibiotic kirromycin inhibits protein synthesis by binding to EF-Tu and preventing its release from the ribosome after GTP hydrolysis. We have isolated and sequenced a collection of kirromycin resistant tuf mutations and identified thirteen single amino acid substitutions at seven different sites in EF-Tu. These have been mapped onto the 3D structures of EF-Tu.GTP and EF-Tu.GDP. In the active GTP form of EF-Tu the mutations cluster on each side of the interface between domains I and III… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…