Mutations that alter the regulation of the chb operon of Escherichia coli allow utilization of cellobiose.

@article{Kachroo2007MutationsTA,
  title={Mutations that alter the regulation of the chb operon of Escherichia coli allow utilization of cellobiose.},
  author={Aashiq H Kachroo and Aswani K Kancherla and Nongmaithem Sadananda Singh and Umesh Varshney and Subramony Mahadevan},
  journal={Molecular microbiology},
  year={2007},
  volume={66 6},
  pages={1382-95}
}
Wild-type strains of Escherichia coli are normally unable to metabolize cellobiose. However, cellobiose-positive (Cel(+)) mutants arise upon prolonged incubation on media containing cellobiose as the sole carbon source. We show that the Cel(+) derivatives carry two classes of mutations that act concertedly to alter the regulation of the chb operon involved in the utilization of N,N'-diacetylchitobiose. These consist of mutations that abrogate negative regulation by the repressor NagC as well as… CONTINUE READING
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