Mutations or copy number losses of CD58 and TP53 genes in diffuse large B cell lymphoma are independent unfavorable prognostic factors

@inproceedings{Cao2016MutationsOC,
  title={Mutations or copy number losses of CD58 and TP53 genes in diffuse large B cell lymphoma are independent unfavorable prognostic factors},
  author={Yuanpeng Cao and Tao Zhu and Peiling Zhang and Min Xiao and Shuhua Yi and Yan Yang and Qinlu Li and Shaoping Ling and Yafei Wang and Lili Gao and Li Zhu and Jue Wang and Na Wang and Liang Huang and Peihong Zhang and Qiong-li Zhai and Lugui Qiu and Jianfeng Zhou},
  booktitle={Oncotarget},
  year={2016}
}
The advent of next generation sequencing (NGS) technologies has expedited the discovery of novel genetic lesions in DLBCL. The prognostic significance of these identified gene mutations is largely unknown. In this study, we performed NGS for the 27 genes most frequently implicated in 196 patients. Interestingly, TP53 mutations were found to be significantly… CONTINUE READING