Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.

@article{Kamenova2014MutationsOT,
  title={Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.},
  author={Ivanka Kamenova and Linda Warfield and Steven Hahn},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 15},
  pages={
          2929-43
        }
}
Most RNA polymerase (Pol) II promoters lack a TATA element, yet nearly all Pol II transcription requires TATA binding protein (TBP). While the TBP-TATA interaction is critical for transcription at TATA-containing promoters, it has been unclear whether TBP sequence-specific DNA contacts are required for transcription at TATA-less genes. Transcription factor IID (TFIID), the TBP-containing coactivator that functions at most TATA-less genes, recognizes short sequence-specific promoter elements in… CONTINUE READING
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