Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.

@article{Shin2001MutationsOT,
  title={Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.},
  author={Myung Seok Shin and Hong Sug Kim and Sug Hyung Lee and Won Sang Park and Su Young Kim and Jik Young Park and Jong Heun Lee and Suk Kyoo Lee and Shi Nae Lee and Sang Seol Jung and Ji Youn Han and Jung Young Lee and Nam Jin Yoo},
  journal={Cancer research},
  year={2001},
  volume={61 13},
  pages={4942-6}
}
Several lines of evidence suggest that apoptosis dysregulation plays an important role in cancer metastasis. In this study, to explore the possibility that the mutations of death receptors are involved in the metastasis mechanism, we analyzed the death domains of Fas and tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 and -2 (TRAIL-R1 and -R2) genes for the detection of somatic mutations in 57 breast cancers with (n = 34) or without (n = 23) metastasis to the regional lymph… CONTINUE READING