Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells

@article{Porcellini1997MutationsOT,
  title={Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells},
  author={Antonio Porcellini and Germana Ruggiano and Silvana Pannain and Ilaria Ciullo and G. V{\'a}zquez Am{\'a}bile and Gianfranco Fenzi and Enrico Vittorio Avvedimento},
  journal={Oncogene},
  year={1997},
  volume={15},
  pages={781-789}
}
TSH receptor mutants in the VI transmembrane segment, found in thyroid autonomously functioning adeonomas, have been expressed in differentiated thyroid cells. All mutant receptors constitutively stimulated adenylyl cyclase. The biological activity, measured as cAMP production relative to the wild type receptor, was specific for each mutant in transient and stable transfection assays. Cells expressing these mutants proliferated in the absence of TSH. The rate of growth in the absence of TSH… CONTINUE READING
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