Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis

@article{Truninger2002MutationsOT,
  title={Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis},
  author={Kaspar Truninger and Heiko Witt and Juliana K{\"o}ck and Andreas Dr Kage and Burkardt Seifert and Rudolf Ammann and H. E. Blum and Michael P.I. Becker},
  journal={American Journal of Gastroenterology},
  year={2002},
  volume={97},
  pages={1133-1137}
}
OBJECTIVE:The pathogenesis of chronic pancreatitis (CP) is poorly understood. Genetic studies revealed mutations in the cationic trypsinogen gene and an increased frequency of cystic fibrosis gene mutations in patients with CP. Recently, a point mutation (N34S) in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), was found in approximately 20% of patients with CP. The aim of our study was to determine the frequency of the N34S SPINK1 gene mutation in a well-defined patient… CONTINUE READING
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