Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group.

@article{FrankRaue1996MutationsOT,
  title={Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group.},
  author={Karin Frank-Raue and Wolfgang Hoeppner and Andrea Frilling and Jorg Kotzerke and Henning 5 Dralle and Richard W. Haase and Klaus Mann and Fayez Seif and Roland Kirchner and Johann Rendl and Harald Deckart and Michael M. Ritter and Rainer Hampel and J Klempa and Gerhard H. Scholz and F Raue},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 5},
  pages={1780-3}
}
It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome. In particular, individuals with a Cys634-Arg substitution should have a greater risk of developing parathyroid disease. We, therefore, analyzed 94 unrelated families from Germany with inherited medullary thyroid carcinoma (MTC) for mutation of the ret protooncogene. In all but… CONTINUE READING