Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system.

@article{Ohgaki1993MutationsOT,
  title={Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system.},
  author={Hiroko Ohgaki and Robert H. Eibl and Manfred Schwab and Martin B. Reichel and Luciano Mariani and Michael E Gehring and Iver Petersen and Thomas H{\"o}ll and Otmar Dieter Wiestler and Paul Kleihues},
  journal={Molecular carcinogenesis},
  year={1993},
  volume={8 2},
  pages={74-80}
}
A variety of neoplasms of the human nervous system were analyzed for the presence of mutations in the p53 tumor suppressor gene. DNA was extracted from frozen or formalin-fixed, paraffin-embedded material. Single-strand conformation polymorphism (SSCP) analysis for exons 5-8 was followed by direct DNA sequencing. Mutations leading to an amino acid change were found in three of 11 (27%) low-grade (World Health Organization (WHO) Grade II) astrocytomas. They were located in codon 183 (TCA-->TGA… CONTINUE READING

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