Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases.

@article{Fenaux1992MutationsOT,
  title={Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases.},
  author={Pierre Fenaux and Philippe Jonveaux and I Quiquandon and Claude Joseph Preudhomme and Jean Luc Lai and Mickael Vanrumbeke and M H Loucheux-Lefebvre and Francis Bauters and Roland Berger and Jean Pierre Kerckaert},
  journal={Leukemia},
  year={1992},
  volume={6 1},
  pages={42-6}
}
Exons 5 to 8 of the p53 gene were examined for mutations in 60 patients with B-cell acute lymphoblastic leukemia (ALL), including 50 cases of precursor-B-cell ALL, nine cases of Burkitt (L3) ALL and one case of atypical ALL with surface immunoglobulins and t(8:14) translocation but L2 morphology. Karyotype was available in all patients. DNA was analyzed by polymerase chain reaction, single strand conformation polymorphism analysis, and nucleotide sequencing. Three patients showed point… CONTINUE READING
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