• Corpus ID: 9783552

Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.

@article{Suh2002MutationsOT,
  title={Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.},
  author={Young Ho Suh and Min Kyung Kim and Young Kee Shin and Seok Hyung Kim and Kwon Ik Oh and Minchan Gil and Yoon-La Choi and Kyeong Cheon Jung and Kyung Mi Lee and Im-Soon Lee and Seong Hoe Park},
  journal={Molecules and cells},
  year={2002},
  volume={13 2},
  pages={
          237-44
        }
}
Hodgkin's disease (HD) is a lymphoid neoplasm characterized by a low frequency of malignant giant tumor cells, known as Hodgkin's and Reed-Sternberg (HRS) cells. Sequence analysis of the immunoglobulin heavy chain hypervariable region (IgH V) genes of HRS cells revealed multiple nucleotide substitutions, indicating somatic mutations, and suggested that HRS cells originate from germinal center B cells or their progeny. We previously reported that CD99-antisense transfected B cell lines led to… 
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The Molecular Basis for the Generation of Hodgkin and Reed-Sternberg Cells in Hodgkin’s Lymphoma

A linkage between LMP1 and HL via CD99, which has recently been reported to be down-regulated by LMP 1 through the NF-κB signaling pathway, leads to the generation of cells with H-RS phenotypes related to the clinical and histologic characteristics of HL.

A concept of essentially secondary factors central to definitive subtype characterization of Hodgkin's disease.

Novel Perspective: Focusing on the X Chromosome in Reproductive Cancers

The human X chromosome contains many genes related to cancer or to sex and reproduction, which suggest that it may play more important roles than any autosomal chromosome in the development and progression of reproductive and urologic cancers.

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