• Corpus ID: 9783552

Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.

  title={Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line.},
  author={Young Ho Suh and Min Kyung Kim and Young Kee Shin and Seok Hyung Kim and Kwon Ik Oh and Minchan Gil and Yoon-La Choi and Kyeong Cheon Jung and Kyung Mi Lee and Im-Soon Lee and Seong Hoe Park},
  journal={Molecules and cells},
  volume={13 2},
Hodgkin's disease (HD) is a lymphoid neoplasm characterized by a low frequency of malignant giant tumor cells, known as Hodgkin's and Reed-Sternberg (HRS) cells. Sequence analysis of the immunoglobulin heavy chain hypervariable region (IgH V) genes of HRS cells revealed multiple nucleotide substitutions, indicating somatic mutations, and suggested that HRS cells originate from germinal center B cells or their progeny. We previously reported that CD99-antisense transfected B cell lines led to… 

The Molecular Basis for the Generation of Hodgkin and Reed-Sternberg Cells in Hodgkin’s Lymphoma

A linkage between LMP1 and HL via CD99, which has recently been reported to be down-regulated by LMP 1 through the NF-κB signaling pathway, leads to the generation of cells with H-RS phenotypes related to the clinical and histologic characteristics of HL.

Novel Perspective: Focusing on the X Chromosome in Reproductive Cancers

The human X chromosome contains many genes related to cancer or to sex and reproduction, which suggest that it may play more important roles than any autosomal chromosome in the development and progression of reproductive and urologic cancers.



Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

The detection of somatic mutations in the rearranged V region genes suggests that both sporadic and endemic BL represent a B-cell malignancy originating from germinal center B cells or their descendants.

Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells.

The high load of V(H) gene mutations and signs of intraclonal diversity suggest a relation between L&H cells and germinal-center B cells at the centroblastic stage of differentiation.

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease.

It appears that several types of oncogene translocations occur as a byproduct of somatic hypermutation within the GC-and not during V(D)J recombination in the bone marrow as previously thought.

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells

Analysis of HRS cells micromanipulated from infiltrated tissue sections of 10 primary HD patients for rearranged V genes suggests that the HRS cell precursors reside inside GCs, have acquired crippling mutations that prevent antigenic selection, but escape apoptosis through some transforming event.

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals, and the mutation pattern was similar to that of Ig genes.

Clonality in nodular lymphocyte-predominant Hodgkin's disease.

Intraclonal variation in nucleotide sequences suggests that hypermutation of the heavy-chain CDR3 continues to occur among the clonal progeny in nodular lymphocyte-predominant Hodgkin's disease.

Generation of cells with Hodgkin's and Reed-Sternberg phenotype through downregulation of CD99 (Mic2).

It is suggested that CD99 molecules play a crucial role in regulating functions and morphology of cells through a Rac-Rho signaling pathway and that the loss of CD99 expression is a significant molecular event to generate H-RS cells.

In vitro triggering of somatic mutation in human naive B cells.

Naive tonsillar B cells sorted for slgD expression can be induced to mutate their Ig V(H) gene upon coculture with activated T cells, thereby providing a model to study somatic hypermutation in vitro.

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.

The VH gene repertoire of human peripheral B cells was analyzed using PCR analysis of individual blood B cells, finding a bias toward VH3 and some of its members was found, indicating that it resulted from molecular and not selective processes.