Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.

@article{Yoshida2005MutationsOT,
  title={Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.},
  author={Yukihiro Yoshida and Tatsuhiro Shibata and Akiko Kokubu and Koji Tsuta and Yoshihiro Matsuno and Yae Kanai and Hisao Asamura and Ryosuke Tsuchiya and Setsuo Hirohashi},
  journal={Lung cancer},
  year={2005},
  volume={50 1},
  pages={1-8}
}
A hypothesis of multistep carcinogenesis of lung adenocarcinoma from atypical adenomatous hyperplasia (AAH) to invasive adenocarcinoma through bronchioloalveolar carcinoma (BAC) has been proposed. However, the genetic alterations that play a role during these processes are not yet clear. Recently, somatic mutations of the epidermal growth factor receptor (EGFR) gene were found in lung adenocarcinoma. We examined the status of EGFR mutations in AAH and BAC to elucidate the role they play during… CONTINUE READING

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