The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation.
- Daichi Iwasaki, Kayoko Hayashihara, +4 authors Miki Shinohara
- PLoS genetics
- 2016
Highly Influenced
5 Excerpts
Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining.
@article{Palmbos2005MutationsOT,
title={Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining.},
author={Phillip Lee Palmbos and James M Daley and Thomas E Wilson},
journal={Molecular and cellular biology},
year={2005},
volume={25 24},
pages={
10782-90
}
}- Published in Molecular and cellular biology 2005
The nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair requires three protein complexes in Saccharomyces cerevisiae: MRX (Mre11-Rad50-Xrs2), Ku (Ku70-Ku80), and DNA ligase IV (Dnl4-Lif1-Nej1). Much is known about the interactions that mediate the formation of each complex, but little is known about how they act together during repair. A comprehensive yeast two-hybrid screen of the NHEJ factors of S. cerevisiae revealed all known interactions within the MRX, Ku, and DNA… CONTINUE READING