Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining.

@article{Palmbos2005MutationsOT,
  title={Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining.},
  author={Phillip Lee Palmbos and James M Daley and Thomas E Wilson},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 24},
  pages={
          10782-90
        }
}
The nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair requires three protein complexes in Saccharomyces cerevisiae: MRX (Mre11-Rad50-Xrs2), Ku (Ku70-Ku80), and DNA ligase IV (Dnl4-Lif1-Nej1). Much is known about the interactions that mediate the formation of each complex, but little is known about how they act together during repair. A comprehensive yeast two-hybrid screen of the NHEJ factors of S. cerevisiae revealed all known interactions within the MRX, Ku, and DNA… CONTINUE READING
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