Mutations of the WT1 gene in childhood nonlymphoid hematological malignancies.

@article{Miyagawa1999MutationsOT,
  title={Mutations of the WT1 gene in childhood nonlymphoid hematological malignancies.},
  author={Kiyoshi Miyagawa and Yasuhide Hayashi and Takahiro Fukuda and Kinuko Mitani and Hisamaru Hirai and Kenichi Kamiya},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={25 2},
  pages={
          176-83
        }
}
The Wilms' tumor gene WT1, whose loss of function accounts for the genesis of about 10% of Wilms' tumors, is expressed in hematopoietic stem cells and leukemia. By analogy with the relationship between the kidney stem cell and Wilms' tumor, it is probable that WT1 is mutated in leukemia. WT1 mutations have been found in only eight cases of primary leukemia, mainly in acute myeloid leukemia (AML) and rarely in acute lymphoblastic leukemia. However, two other studies have demonstrated the absence… CONTINUE READING
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