Mutations of the Homeobox Genes Dlx-1 and Dlx-2 Disrupt the Striatal Subventricular Zone and Differentiation of Late Born Striatal Neurons

@article{Anderson1997MutationsOT,
  title={Mutations of the Homeobox Genes Dlx-1 and Dlx-2 Disrupt the Striatal Subventricular Zone and Differentiation of Late Born Striatal Neurons},
  author={Stewart A. Anderson and Mengsheng Qiu and Alessandro Bulfone and David D Eisenstat and Juanito Meneses and Roger Pedersen and John L. Rubenstein},
  journal={Neuron},
  year={1997},
  volume={19},
  pages={27-37}
}
The striatum has a central role in many neurobiological processes, yet little is known about the molecular control of its development. Inroads to this subject have been made, due to the discovery of transcription factors, such as the Dlx genes, whose expression patterns suggest that they have a role in striatal development. We report that mice lacking both Dlx-1 and Dlx-2 have a time-dependent block in striatal differentiation. In these mutants, early born neurons migrate into a striatum-like… CONTINUE READING
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