Mutations of the Drosophila zinc finger-encoding gene vielfältig impair mitotic cell divisions and cause improper chromosome segregation.

@article{Staudt2006MutationsOT,
  title={Mutations of the Drosophila zinc finger-encoding gene vielf{\"a}ltig impair mitotic cell divisions and cause improper chromosome segregation.},
  author={Nicole Staudt and Sonja Fellert and Ho-Ryun Chung and Herbert Jaeckle and Gerd Vorbrueggen},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 5},
  pages={
          2356-65
        }
}
We describe the molecular characterization and function of vielfältig (vfl), a X-chromosomal gene that encodes a nuclear protein with six Krüppel-like C2H2 zinc finger motifs. vfl transcripts are maternally contributed and ubiquitously distributed in eggs and preblastoderm embryos, excluding the germline precursor cells. Zygotically, vfl is expressed strongly in the developing nervous system, the brain, and in other mitotically active tissues. Vfl protein shows dynamic subcellular patterns… CONTINUE READING

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