Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors

  title={Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors},
  author={Detlef Bartsch and Stephan A. Hahn and Kirill D Danichevski and Annette Ramaswamy and Daniel Bastian and Hamid Galehdari and Peter Barth and Wolff Schmiegel and Babette Simon and Matthias Rothmund},
Tumors of the endocrine pancreas are extremely rare, and molecular mechanisms leading to their development are not well understood. A candidate tumor suppressor gene, DPC4, located at 18q21, has recently been shown to be inactivated in half of pancreatic adenocarcinoma xenografts. The close anatomical relationship of the exocrine and endocrine pancreas prompted us to determine the role of DPC4 in the tumorigenesis of 25 pancreatic islet cell tumors (11 insulinomas, nine non-functioning… CONTINUE READING


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