Mutations of the BRAF gene in squamous cell carcinoma of the head and neck

  title={Mutations of the BRAF gene in squamous cell carcinoma of the head and neck},
  author={Anette Weber and Larissa Langhanki and Florian Sommerer and Annett Markwarth and Christian Wittekind and Andrea Tannapfel},
The RAF/MEK/ERK (MAPK) signal transduction cascade is an important mediator of a number of cellular fates including growth, proliferation and survival. The BRAF gene, one of the human isoforms of RAF, is activated by oncogenic RAS, leading to cooperative effects in cells responding to growth factor signals. This study was performed to elucidate a possible function of BRAF in squamous cell carcinoma of the head and neck (HNSCC). Mutations of BRAF and KRAS2 were evaluated in 89 HNSCC and… CONTINUE READING


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