Mutations of fibroblast growth factor receptor 3 gene (FGFR3) in transitional cell carcinoma of urinary bladder in Thai patients [Revision-2a].

@article{Jantip2013MutationsOF,
  title={Mutations of fibroblast growth factor receptor 3 gene (FGFR3) in transitional cell carcinoma of urinary bladder in Thai patients [Revision-2a].},
  author={Jariya Jantip and Montira Tanthanuch and Samornmas Kanngurn and Watid Karnchanawanichkul and Choosak Pripatnanont and Surasak Sangkhathat and Paramee Thongsuksai},
  journal={Journal of the Medical Association of Thailand = Chotmaihet thangphaet},
  year={2013},
  volume={96 8},
  pages={976-83}
}
OBJECTIVE Determine the incidence of FGFR3 mutations in Thai patients with bladder transitional cell carcinoma (TCC), and evaluate their correlation with pathological characteristics. MATERIAL AND METHOD One hundred twenty two frozen tissue samples from TCC patients were analyzed for mutations in exons 7, 10, and 15 of FGFR3 by polymerase chain reaction and direct DNA sequencing. RESULTS FGFR3 mutations were detected in 22 of 122 cases (18%) studied, all of which were found within… CONTINUE READING

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