Mutations of epigenetic regulatory genes are common in thymic carcinomas

@inproceedings{Wang2014MutationsOE,
  title={Mutations of epigenetic regulatory genes are common in thymic carcinomas},
  author={Yisong Wang and Anish J Thomas and C. Christopher Lau and Arun Rajan and Yuelin Jack Zhu and Jonathan Keith Killian and Iacopo Petrini and Trung C Pham and Betsy Morrow and Xiaogang Zhong and Paul S. Meltzer and Guiseppe Giaccone},
  booktitle={Scientific reports},
  year={2014}
}
Genetic alterations and etiology of thymic epithelial tumors (TETs) are largely unknown, hampering the development of effective targeted therapies for patients with TETs. Here TETs of advanced-stage patients enrolled in a clinical trial of molecularly-guided targeted therapies were employed for targeted sequencing of 197 cancer-associated genes. Comparative sequence analysis of 78 TET/blood paired samples obtained from 47 thymic carcinoma (TC) and 31 thymoma patients revealed a total of 86… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
18 Citations
69 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 69 references

A phase II study of milciclib (PHA-848125AC) in patients (pts) with thymic carcinoma (TC)

  • B Besse
  • J Clin Oncol 32:5s, Suppl; abstr 7526–7526
  • 2014
1 Excerpt

Phase II trial of sunitinib in patients with thymic epithelial tumors (TET)

  • A Thomas
  • J Clin Oncol 32:5s, suppl; abstr 7525–7525
  • 2014
2 Excerpts

The landscape of somatic mutations in epigenetic regulators across 1 , 000 paediatric cancer genomes

  • R. Huether
  • Nat Commun
  • 2014

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer

  • R Huether
  • genomes. Nat Commun
  • 2014

a multicentre, open-label, phase 2 trial

  • Rajan, A. et al. Cixutumumab for patients with recurrent or tumours
  • Lancet Oncol 15, 191–200
  • 2014

Similar Papers

Loading similar papers…