Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors.

@article{Tissier2005MutationsOB,
  title={Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors.},
  author={Fr{\'e}d{\'e}rique Tissier and Catherine Cavard and Lionel Groussin and Karine Perlemoine and Gwladys Fumey and Anne-Marie Hagn{\'e}r{\'e} and Fernande Ren{\'e}-Corail and Eric Jullian and Christine Gicquel and Xavier Y. Bertagna and Marie-C{\'e}cile Vacher-Lavenu and Christine Perret and J{\'e}r{\^o}me Bertherat},
  journal={Cancer research},
  year={2005},
  volume={65 17},
  pages={
          7622-7
        }
}
Adrenocortical cancer is a rare cancer with a very poor prognosis. The genetic alterations identified to date in adrenocortical tumors are limited. Activating mutations of the Wnt signaling pathway have been observed in more frequent cancers, particularly digestive tract tumors. We investigated whether Wnt pathway activation is involved in adrenocortical tumorigenesis. In a series of 39 adrenocortical tumors, immunohistochemistry revealed abnormal cytoplasmic and/or nuclear accumulation of beta… CONTINUE READING

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