Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy

Abstract

Congestive heart failure (CHF) can result from various disease states with inadequate cardiac output. CHF due to dilated cardiomyopathy (DCM) is a familial disease in 20–30% of cases and is associated with mutations in genes encoding cytoskeletal, contractile or inner–nuclear membrane proteins. We show that mutations in the gene encoding giant-muscle… (More)
DOI: 10.1038/ng815

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