Mutations of TGFbeta signaling molecules in human disease.

  title={Mutations of TGFbeta signaling molecules in human disease.},
  author={Kelly A Harradine and Rosemary J. Akhurst},
  journal={Annals of medicine},
  volume={38 6},
The transforming growth factor beta (TGFbeta) signaling pathway regulates several biological processes including cellular proliferation, differentiation, apoptosis, migration, and extracellular matrix deposition. Ligand and receptor family members signal through two main Smad signaling branches, TGFbeta/activin to Smad2/3 (Sma and MAD-related proteins) and bone morphogenetic protein (BMP) to Smad1/5. At the molecular level, TGFbeta acts by modifying cytoskeletal organization and ultimately… CONTINUE READING


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