Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

@article{Broderick2004MutationsOP,
  title={Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas},
  author={Daniel K Broderick and Chunhui Di and Timothy J. Parrett and Yardena Samuels and Jordan M. Cummins and Roger E. McLendon and Daniel W. Fults and Victor E. Velculescu and Darell D. Bigner and Hai Yan},
  journal={Cancer Research},
  year={2004},
  volume={64},
  pages={5048 - 5050}
}
The phosphatidylinositol 3′-kinase pathway is activated in multiple advanced cancers, including glioblastomas, through inactivation of the PTEN tumor suppressor gene. Recently, mutations in PIK3CA, a member of the family of phosphatidylinositol 3′-kinase catalytic subunits, were identified in a significant fraction (25–30%) of colorectal cancers, gastric cancers, and glioblastomas and in a smaller fraction of breast and lung cancers. These mutations were found to cluster into two major “hot… 
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PIK3CA mutations in glioblastoma multiforme
TLDR
The frequency of PIK3CA mutations in glioblastomas appears to be much lower than initially reported, supporting the concept of mutational hot spot regions.
PIK3CA Gene Mutations in Pediatric and Adult Glioblastoma Multiforme
TLDR
It is confirmed that PIK3CA mutations occur in a significant number of human glioblastomas, further indicating that therapeutic targeting of this pathway in gliOBlastomas is of value and providing a molecular target in this important pediatric malignancy.
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TLDR
It is demonstrated that PIK3CA mutations, like alterations in other PI3K catalytic and regulatory subunit genes [5], are not frequent events in glioblastoma.
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TLDR
Mapping the mutated genes into known signaling pathways revealed that the large majority of them plays a central role in the PI3K-AKT pathway, which should offer new opportunities for the rational development of therapeutic approaches for glioblastomas.
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TLDR
Findings indicate that mutant PIK3CA is likely to function as an oncogene among ATC and less frequently well-differentiated thyroid carcinomas, and argue for a role of Pik3CA targeting in the treatment of ATC patients.
PIK3CA Mutations in Diffuse Gliomas: An Update on Molecular Stratification, Prognosis, Recurrence, and Aggressiveness
TLDR
Despite the absence of a predominant effect in glioma stratification, PIK3CA mutations were maintained during Glioma recurrence, possibly contributing toglioma cell survival, representing promising therapeutic targets in recurrent gliomas.
Association of PIK3CA gene mutations with head and neck squamous cell carcinomas.
TLDR
The distribution of mutations of PIK3CA in HNSCC were associated with demographic (tobacco and alcohol) and clinical parameters (advanced stage, primary site) of H NSCC, and it is possible that when this pathway is overactive due to mutations, it may reduce apoptosis and allow proliferation of the tumor cells.
PIK3CA Mutations in Intraductal Papillary Mucinous Neoplasm/Carcinoma of the Pancreas
TLDR
Evidence is provided that the oncogenic properties of PIK3CA contribute to the tumorigenesis of IPMN/IPMC, the first report of Pik3CA mutation in pancreatic cancer.
PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas
TLDR
The first report of PIK3CA mutation in pancreatic cancer appears to be the first oncogene to be mutated in IPMN/IPMC but not in conventional ductal adenocarcinoma of the pancreas.
PIK3CA mutations in nasopharyngeal carcinoma
Dear Sir, By molecular cytogenetic studies, we have previously identified high frequency of copy number gain or amplification on chromosomes 3q (70%) in nasopharyngeal carcinoma (NPC), a prevalence…
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