Mutations of NKX2.5 and GATA4 genes in the development of congenital heart disease.

@article{Tong2016MutationsON,
  title={Mutations of NKX2.5 and GATA4 genes in the development of congenital heart disease.},
  author={Yi-Fan Tong},
  journal={Gene},
  year={2016},
  volume={588 1},
  pages={
          86-94
        }
}
OBJECTIVE To investigate the mutations of NKX2.5 and GATA4 genes in the development of CHD in Chinese population. METHODS Between December 2010 and December 2014, 185 cases of CHD patients and 210 cases of healthy people were enrolled. NKX2.5 and GATA4 gene mutations and gene expression were detected via DNA sequencing and real-time PCR (RT-PCR), respectively. BMSCs were transfected with pCMV-HA-NKX2.5 and pCMV-Myc-GATA4 plasmids. Cardiac troponin T (cTnT) and connexin 43 (Cx43) and β-myosin… CONTINUE READING
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