Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance.

  title={Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance.},
  author={Martina Morrin and Margaret Kelly and Nigel Barrett and Peter G. Delaney},
  volume={35 11},
The series of genetic changes leading to malignancy in colorectal cancer is well reported. This includes mutational activation of the proto-oncogene Ki-ras and mutation/deletion of the p53 tumour suppressor gene. The frequency of these mutations was investigated in a panel of 52 colorectal cancer patients using a combination of immunocytochemistry and non-radioactive, digoxigenin-labelled in situ hybridisation. Sixty two per cent (32 of 52) of the study population were positive for p53… CONTINUE READING
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