Mutations of GJB2 in three geographic isolates from northern Tunisia: evidence for genetic heterogeneity within isolates.

@article{Arab2000MutationsOG,
  title={Mutations of GJB2 in three geographic isolates from northern Tunisia: evidence for genetic heterogeneity within isolates.},
  author={Sa{\"i}da Ben Arab and Mounira Hmani and Françoise Denoyelle and Amel Boulila-Elgaied and Sebastian Chardenoux and Slah Hachicha and Christine Petit and Hammadi Ayadi},
  journal={Clinical genetics},
  year={2000},
  volume={57 6},
  pages={439-43}
}
Geographically isolated populations have been successfully used to localize genes for recessive inherited diseases, including non-syndromic sensorineural recessive deafness (NSRD). To date, 25 loci for NSRD have been localized on human chromosomes (DFNB loci), and six of the corresponding genes have been identified. Here, we report on the contribution of the DFNB1 locus (GJB2 gene) to NRSD in seven affected families living in three northern Tunisian geographic isolates, and we provide evidence… CONTINUE READING

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