Mutations of CCNF gene is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China.

@article{Pan2017MutationsOC,
  title={Mutations of CCNF gene is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China.},
  author={Chuzheng Pan and Bin Jiao and Tingting Xiao and Li-hua Hou and Weiwei Zhang and Xi Liu and Jun Xu and Beisha Tang and L i Sh{\'e}n},
  journal={Amyotrophic lateral sclerosis & frontotemporal degeneration},
  year={2017},
  volume={18 3-4},
  pages={265-268}
}
OBJECTIVE Mutations of the cyclin F (CCNF) gene were recently identified to be associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Western and Japanese populations. The rare protein-altering variants frequency is 0.6 to 3.3% in ALS and FTD from these diverse geographic populations while no systematic analysis of CCNF variants were conducted in the Chinese population. METHODS We screened all exons of CCNF in a cohort of 269 cases (including 181 ALS and 88… CONTINUE READING

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