Mutations of BRAF and RAS are rare events in germ cell tumours.

  title={Mutations of BRAF and RAS are rare events in germ cell tumours.},
  author={Florian Sommerer and Ulrich R. Hengge and Annett Markwarth and Susanne Vomschloss and Jens-Uwe Stolzenburg and Christian Wittekind and Andrea Tannapfel},
  journal={International journal of cancer},
  volume={113 2},
The BRAF gene, one of the human isoforms of RAF, is activated by oncogenic Ras, leading to cooperative effects in cells responding to growth factor signals. Recently, somatic missense mutations in the BRAF gene have been detected in a variety of human tumors. We have studied male germ cell tumours (GCT) for probable mutations of the BRAF and Ras oncogene. Microsatellite instability (MSI) was analysed using mono- or di-nucleotide marker. Mutational analysis of 62 GCT (30 seminomas and 32… CONTINUE READING
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