Mutations occurring during serial passage of Japanese equine infectious anemia virus in primary horse macrophages.

@article{Zheng2000MutationsOD,
  title={Mutations occurring during serial passage of Japanese equine infectious anemia virus in primary horse macrophages.},
  author={Yao Hu Zheng and Hiroshi Sentsui and Yuki Kono and Kazufumi Ikuta},
  journal={Virus research},
  year={2000},
  volume={68 1},
  pages={93-8}
}
An attenuated equine infectious anemia virus (EIAV), named V26, was previously obtained after 50 passages of the Japanese virulent strain V70 in primary macrophage culture. To clarify the differences between both viruses, their full-length sequences were determined. There were higher mutations in S2 (6.15% amino acid difference) and LTR (10.7% nucleotide difference). The presumed initiation codon of the S2 gene was absent from the sequence of V26. There was a large insertion within the long… CONTINUE READING

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There were higher mutations in S2 ( 6.15% amino acid difference ) and LTR ( 10.7% nucleotide difference ) .
There were higher mutations in S2 ( 6.15% amino acid difference ) and LTR ( 10.7% nucleotide difference ) .
There was a large insertion within the long - terminal repeat ( LTR ) U3 hypervariable region of V26 .
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