Mutations introduced along the HTLV-I envelope gene result in a non-functional protein: a basis for envelope conservation?

@article{Pique1990MutationsIA,
  title={Mutations introduced along the HTLV-I envelope gene result in a non-functional protein: a basis for envelope conservation?},
  author={Claudine Pique and Thomas Tursz and M C Dokh{\'e}lar},
  journal={The EMBO journal},
  year={1990},
  volume={9 13},
  pages={4243-8}
}
The envelope protein of the human T-cell leukemia virus type I (HTLV-I) is highly conserved among the isolates sequenced so far, as opposed to what is observed for the human immunodeficiency virus (HIV) envelope. By linker insertion scanning, we have produced 33 random mutations along the HTLV-I envelope gene, cloned into a eukaryotic expression vector. The resulting envelope products were analysed by immunoprecipitation and syncytia formation after transfection into COS-1 cells. We show here… CONTINUE READING

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