Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.

@article{Callahan2003MutationsIY,
  title={Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.},
  author={Julie L Callahan and Kenneth S. Andrews and Virginia A. Zakian and Catherine H Freudenreich},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 21},
  pages={
          7849-60
        }
}
Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replication and both stability and fragility of TNRs. We devised a new yeast artificial chromomosme (YAC)-based assay for chromosome breakage to analyze fragility of CAG/CTG tracts in mutants deficient for… CONTINUE READING
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