Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.

@article{Waters2009MutationsIT,
  title={Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.},
  author={Joshua M Waters and Wesley T O'Neal and Kirsten Lofgren White and Charles Wakeford and Eric B Lansdon and Jeanette L Harris and Evguenia S. Svarovskaia and Michael D. Miller and Katyna Borroto-Esoda},
  journal={Antiviral therapy},
  year={2009},
  volume={14 2},
  pages={231-9}
}
BACKGROUND Antiretroviral therapy that targets HIV type-1 (HIV-1) reverse transcriptase (RT) can be linked to mutations in the thumb-connection (amino acids [AA] 241-426) and RNase H (AA 427-560) domains, which could affect drug resistance. METHODS Genotypical and statistical analyses were performed on HIV-1 RT from 100 antiretroviral treatment-naive and 248 antiretroviral treatment-experienced patients, the majority of whom were infected with HIV-1 subtype B. The RT region was analysed in… CONTINUE READING
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