Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells

@article{Xu1999MutationsIT,
  title={Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells},
  author={Yong Xu and Anuradha Krishnan and X. Steven Wan and Hideyuki Majima and Che-chung Yeh and Gabriele Ludewig and Edward J. Kasarskis and Daret K. St. Clair},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={93-102}
}
Manganese superoxide dismutase (MnSOD) has been shown to play an important role in preventing the development of cancer. MnSOD activity is reduced in many transformed cells and tumor tissues. We previously showed that the reduced level of MnSOD activity in cancer cells was not due to a defect in the primary structure of MnSOD protein, but rather was due to defects in gene expression. To elucidate the cause for the reduced expression of human MnSOD in cancer, we investigated the nucleotide… CONTINUE READING

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