Mutations in the pore regions of the yeast K+ channel YKC1 affect gating by extracellular K+.

@article{Vergani1998MutationsIT,
  title={Mutations in the pore regions of the yeast K+ channel YKC1 affect gating by extracellular K+.},
  author={P Vergani and Dawn Hamilton and Simon M. Jarvis and Michael R Blatt},
  journal={The EMBO journal},
  year={1998},
  volume={17 24},
  pages={7190-8}
}
The product of the Saccharomyces cerevisiae K+-channel gene YKC1 includes two pore-loop sequences that are thought to form the hydrophilic lining of the pore. Gating of the channel is promoted by membrane depolarization and is regulated by extracellular K+ concentration ([K+]o) both in the yeast and when expressed in Xenopus oocytes. Analysis of the wild-type current now shows that: (i) [K+]o suppresses a very slowly relaxing component, accelerating activation; (ii) [K+]o slows deactivation in… CONTINUE READING

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The structure of the potassium channel: molecular basis of K conduction and selectivity

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