Mutations in the p53 gene and human papillomavirus infection as significant prognostic factors in squamous cell carcinomas of the oral cavity.

@article{Chiba1996MutationsIT,
  title={Mutations in the p53 gene and human papillomavirus infection as significant prognostic factors in squamous cell carcinomas of the oral cavity.},
  author={Itsuo Chiba and Masanobu Shindoh and Motoaki Yasuda and Yukari Yamazaki and Akira Amemiya and Yoshiya Sato and Kei Fujinaga and Ken-ichi Notani and Hiroshi Fukuda},
  journal={Oncogene},
  year={1996},
  volume={12 8},
  pages={1663-8}
}
The p53 gene has been indicated to be a tumour suppressor gene that is found in mutated form in common human cancers. Human papillomavirus (HPV) has oncogenic activity in cervical and oral squamous cell carcinomas (SCCs). The E6 protein of HPV is known to bind with p53 protein and inactive the tumor suppressor activity by promoting p53 degradation. Because of this background, we examined 38 primary, resected specimens of oral SCCs for detection of p53 mutations and HPV DNAs. Exons 5 through 8… CONTINUE READING

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