Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

@article{Brentnall1994MutationsIT,
  title={Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.},
  author={Teresa A. Brentnall and David A. Crispin and PeterS. Rabinovitch and Rodger C. Haggitt and Cyrus E. Rubin and Anthony Christopher Lee Stevens and Glenna C. Burmer},
  journal={Gastroenterology},
  year={1994},
  volume={107 2},
  pages={
          369-78
        }
}
BACKGROUND/AIMS In long-term extensive ulcerative colitis, aneuploidy occurs earlier and loss of heterozygosity for p53 (p53 LOH) later during histological progression towards carcinoma. This study determined the time of onset of p53 mutation in this progression. METHODS We developed a rapid, sensitive screening assay for p53 mutations at codon 248. The geographic distribution of this p53 mutation was mapped in two fresh colectomy specimens with mutations of codon 248 (1 cancer, 1 dysplasia… CONTINUE READING
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