Mutations in the p . 53 Gene in Lung Cancer Are Associated with Cigarette Smoking and Asbestos Exposure 1

@inproceedings{Wang2005MutationsIT,
  title={Mutations in the p . 53 Gene in Lung Cancer Are Associated with Cigarette Smoking and Asbestos Exposure 1},
  author={Xi Wang and David C. Christiani and John K. Wiencke and Michael Fischbein and Xiping Xu and Tsun J Cheng and Eugene Jerome Mark and John C. Wain and Karl T. Kelsey},
  year={2005}
}
It has been proposed that the patterns of mutations in the p53 tumor suppressor gene will provide clues to the mechanisms of cancer occurrence. Cigarette smoking is known to be the greatest risk factor for lung cancer. Epidemiological evidence has also implicated radon and asbestos as exposures that significantly increase this disease risk; asbestos exposure synergistically enhances the lung cancer risk of smokers. Previous studies of the mutational spectra of the p53 gene in lung cancer have… CONTINUE READING