Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.

@article{Ando2013MutationsIT,
  title={Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.},
  author={Koji Ando and Hideki Tsushima and Emi Matsuo and Kensuke Horio and Shinya Tominaga-Sato and Daisuke Imanishi and Yoshitaka Imaizumi and Masako Iwanaga and Hidehiro Itonaga and Shinichiro Yoshida and Tomoko Hata and Ryozo Moriuchi and Hitoshi Kiyoi and Stephen Nimer and Hiroyuki Mano and Tomoki Naoe and Masao Tomonaga and Yasushi Miyazaki},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 13},
  pages={9457-67}
}
Myeloid ELF1-like factor (MEF/ELF4), a member of the ETS transcription factors, can function as an oncogene in murine cancer models and is overexpressed in various human cancers. Here, we report a mechanism by which MEF/ELF4 may be activated by a common leukemia-associated mutation in the nucleophosmin gene. By using a tandem affinity purification assay, we found that MEF/ELF4 interacts with multifactorial protein nucleophosmin (NPM1). Coimmunoprecipitation and GST pull-down experiments… CONTINUE READING
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Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation.

Proceedings of the National Academy of Sciences of the United States of America • 2008
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