Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families.


BACKGROUND Lysyl oxidase is a promising candidate gene for a mutation search in intracranial aneurysm families because (a) it controls the processing, cross-linking and maturation of collagen and elastin fibers in the blood vessel wall, (b) its expression levels and activity are altered in different animal models of aneurysm pathogenesis, and (c) it is… (More)


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