Mutations in the lspA1 and lspA2 genes of Haemophilus ducreyi affect the virulence of this pathogen in an animal model system.

@article{Ward2003MutationsIT,
  title={Mutations in the lspA1 and lspA2 genes of Haemophilus ducreyi affect the virulence of this pathogen in an animal model system.},
  author={Christine K. Ward and J. L. Latimer and Joseph R Nika and Merja Vakevainen and Jason R Mock and Kaiping Deng and Robert J. Blick and Eric J. Hansen},
  journal={Infection and immunity},
  year={2003},
  volume={71 5},
  pages={2478-86}
}
Haemophilus ducreyi 35000HP contains two genes, lspA1 and lspA2, whose predicted protein products have molecular weights of 456,000 and 543,000, respectively (C. K. Ward, S. R. Lumbley, J. L. Latimer, L. D. Cope, and E. J. Hansen, J. Bacteriol. 180:6013-6022, 1998). We have constructed three H. ducreyi 35000HP mutants containing antibiotic resistance… CONTINUE READING