Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir.

@article{Chou2004MutationsIT,
  title={Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir.},
  author={Sunwen Chou and Gail I. Marousek and Anne E. Senters and Michelle G. Davis and Karen K. Biron},
  journal={Journal of virology},
  year={2004},
  volume={78 13},
  pages={
          7124-30
        }
}
Previous drug selection experiments resulted in the isolation of a human cytomegalovirus (CMV) UL97 phosphotransferase mutant resistant to the benzimidazole compound maribavir (1263W94), reflecting the anti-UL97 effect of this drug. Three other CMV strains were plaque purified during these experiments. These strains showed lower-grade resistance to maribavir than the UL97 mutant. Extensive DNA sequence analyses showed no changes from the baseline strain AD169 in UL97, the genes involved in DNA… CONTINUE READING

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